Progesterone Intolerance | Anxiety, Depression and other Side Effects

I just want to say a BIG THANK YOU for actually replying to so many comments on your channel. Unlike other Menopause/Hormone channels, where the doctor or expert just gives standard answers like, "seek advice from your MD" or "thanks for sharing your experience" without giving any constructive advice. Even if it's general advice, not tailored to the individual, at least answer the question to the best you can. ONLY you do that from what I can see. SO THANK YOU!

great experience with progesterone… helped with insomnia on the 100. mg dose but when up to 150 mg unable to control bladder… and NEVER EVER had a problem with it before

I want to use HRT but the progesterone/prometreum makes me very depressed. crying, etc. My menopause symptoms are mostly very itchy skin, hot flashes, looking old, hair falling out…not sure what to do?

Talk about CYCLING progest. We’re not supposed to have the same levels all month long. It’s unnatural and of course it throws us off. Supposed to cycle it

I felt terrible mood and physically exhausted during my 4th pregnancy (at 40) felt so much better after birth, then got a marina IUD and felt like total shit again, sweating just from taking a few steps, burning and inflammation in my back and extreme pain and more… I don’t know for sure but I suspect progesterone intolerance.

I cannot tolerate oral progesterone. It gives my gastritis…I am a bariatric patient, so def didn't need that. I am now trying vaginal suppositories to protect the uterus. If these don't work out, what else is there? I am on the estrogen patch and have my uterus so I know its essential to keep from getting uterine cancer. I use an online provider and she said I am the first person she has seen that cannot tolerate oral progesterone, so the suppositories were the one thing they knew we could try so I don;t have to get an IUD

Was taking BHRT from Winona (cream) amd it resolved night sweats. But was still a bit low energy. Decided to try an estrogen patch and 100mg micronized progesterone. No anxiety or depression, but the CRUSHING fatigue is killing me. I wish there was such a thing as a hormone balancing specialist. Current doctor just wants to push Mirena. But i have NEVER reacted well to any form of BC. Not inclined to stick pokey foreign objects anywhere near sensitive female parts. I do NOT want any synthetic progestin. Feeling like ill never get any answers.

I’ve developed a tolerance to progesterone cream. Now nothing works.

I litterly feel like you are telling my story! I am in the midst of trying to explain to my provider that the progesterone is not agreeing with my body and I have severe PMDD! She upped my dosage of Progesterone recently and it sent me into a depressed state that I have never seen. I desperately need help. How do I contact you?

Mi name is Monica Hernandez and I recently found out that I am allergic to progesterone. Twelve years ago doctors diagnosed me with endometriosis and put me for over a year in an induced menopause. During that time I took 4 pills, each of them drive me crazy, I had 23, but after I stopped to take it I come back to be myself, but the last pill was medroxiprogesterone, when I finished to take that one, I never come back to be me, that was the hardest pill and I was able to take it only for three months. I had a very good memory my whole life and after that pill I couldn't even remember those three months. I felt incapable to learn anything during those three months and I am talking that before I studied nuclear physics and I graduated with honors. After I finished with that pill for the next twelve years I keep having the same symptoms every month around the same period of time and I knew was related with my period but doctors said was premenstrual syndrome. I change I feel myself at the beginning of my periods and after ovulation I was as a different person. I had migraine my memory my ability to learn I felt like crazy. After 10 years I started to have issues with my beings, I have two laser ablation in my legs two stains in my back, and in 2023 I had a partial hysterectomy for inflammatory pelvic syndrome. During all this years I keep complaining with the doctors about how I feel every month I had liquid retention and so many symptoms that sometimes I didn't want it to live like that anymore. My life is still a nightmare and doctors keep doing blood test and telling me that I was healthy and young but I didn't feel like that. I even went to therapy, anything that can help me, my gynecologist keep telling me that wasn't my ovaries keep sending me to different specialists that they didn't founded anything and at this point every time I go to see a doctor after 12 years I just break and cry. I been fighting with this and keep saying that I was sick until a couple of weeks ago. Oh I forgot after the partially histerectomy my symptom get better I gained control over my emotions
I pointed that to my gynecologist but he didn't want to take the other ovary because I am 35. The ovary that I have is not working 100 % and I get small cysts and I had to start to take estradiol 2mg and the endocrinologist told me to take progesterone for my sleep issues. I tooked one day and after one pill I had the same annoying symptoms that I get every month after my ovulation even the rash. I went to see my immunologist because occur to me that perhaps I could be allergic to progesterone. They put me before in different contraceptives pills and I never was able to take it for more than two months, but I was tolerating the stradiol along and the progesterone only one pill and put me in the worth day of my month. Anyway I went with her she run and allergy test I hit positive, she makes me take a progesterone test when I am fine and when I am sick a couple of times and every time that I am sick my levels of progesterone are high, matching with the second part of my cycle. So after 12 years finally I got an answer. I am scared now because I still need to present the results to my gynecologist and I don't trust in him anymore and I do not know what to do. I took different contraceptives pills before and I couldn't handle they side effects I think that in my case take the ovary will be the best since I only have one, that hurts a lot every month during ovulation because the cyst, and drive me crazy but they only talk about the negative consequences of the menopause, my age and at the end I feel that I don't have any hope to get better and I am scared for the sleep part. I didn't found any endocrinologist that actually helps me even my told me that the allergy to progesterone was rear that he wouldn't know how to prove it. Anyway if you can help me somehow I will appreciate a lot. I am sorry for my English my primary language is Spanish.

Hello and thanks for all the information. Unfortunately, I get vaginal yeast infection when I take progesterone (utrogestan). Has anyone else had this problem, why does it happen, I wonder

I'm having severe urticaria due to progesterone…. what is the solution doctor please help , I'm 50

So, I was on Everol Conti, it’s worked until after around 8 months hot sweat and other symptoms appeared again, also, even though I hadn’t had a menstruation for 18months from starting my HRT, I started to have a monthly bleed and this didn’t stop, I had a biopsy which was clear.. I changed my HRT to Estrogen gel and progesterone pil 100g, bleed had stopped but I am feeling extreme emotion and suicidal ideations. I didnt have this symptom with Everol Conti. It’s such a hard place to be and wasn’t coping well with menopause symptoms. I’m coming back as a Cat in my next life!
Conti, but I did continue to bleed and it seemed to
Pla

Do these side effects go away

Is progesterone appropriate for a 67 year old post menopausal woman

Can a progesterone of 800mg everyday increase anxiety? I am feeling anxious very anxious since the time my progesterone supplements have been added

I am on micronised Protestan and etstrogen spray. I suffered quickly on oral progestan and now insert half dosage every second night . This appears to be working although have noticed sore gums and ears

I’m taking 100 mg of progesterone at night it helps me sleep it’s a God send I couldn’t sleep only about 3 sometimes 4 hours!! The only thing is I noticed I’m getting some pimples no other side effects

What a blessing this video is!!!
Almost immediately got severe anxiety, panic attacks, irritation 10/10. I sleep max 4 hours total plus waking up 4-5 times a night.
Literally hell

I have bizarre mood swings, dizziness, nausea, PMDD, depression, intrusive thoughts. The internist and gino suspect endometriosis as I also have raging pain during ovulation up until I start bleeding. I am often anxious and faint, sometimes sleep way too long and cant function, so I basically function like normal person only 7 days out of the entire cyclus. I'm sporty person, 34, skinny, i eat healthy I dont take sugar. I used to never get sick before 3 years ago, now my immune system falls apart every ovulation. I get fever flashes and inflammation that hurts and spreads to the lower back. Sometimes my chest hurts and I have trouble breathing. What kind of contraception or hormonal therapy do you suggest? I keep going from doctor to doctor and no one takes me seriously. One doctor gave me pills for insulin resistance for my PCOS.

I’ve heard topical is best and that there may be a progesterone kick back and then you’d need to take larger dose. Thoughts?

Omg – I had terrible progesterone intolerance for 18 months when I first started HRT. I was told to take 200 ml oral progesterone for 14 days of the month and I went into a severe depression and cried every single day for 18 months, and I had no idea that I was causing this to my mental state until I read someone else’s experience on Reddit. I thought I was just having a dark night of the soul, and I also couldn’t figure out why I was so angry (I wasn’t angry at a specific person – just had rage inside of me). I’ve never been depressed in my life, but progesterone altered my neurochemistry so much that I signed up for an ayahuasca ceremony – and multiple other ceremonies to try to snap myself out of the depression. Once I read about another woman’s depressive experience on progesterone I stopped taking it and the clouds parted and I became my old self again. Now I’m just angry there’s so little knowledge about women’s health that I had to needlessly suffer for so long. I feel so bad for others who are doing the same as they are just following their doctors advice to take the progesterone and end up with a terrible reaction that they don’t connect to that hormone. I know we have to take it if we are taking Estrodiol, but I’m told that if we can take it transdermally, we can get it in lower doses and it will bypass our liver so we won’t have such strong side affects.

If women aren't taking a high dose of Magnesium Glycinate at night you are going to sleep well.

I am 54 I was having problems with progesterone and I started taking through the vagina and I have been fine!!!